IHUT (Intracranial and Intraventricular Hemorrhage with Ultrasound Enhanced Thrombolysis)

Focus: 

To demonstrate that ultrasound can accelerate the delivery of drugs to improve stroke treatment

Anticipated Impact: 

Improved outcomes for stroke patients

Abstract: 

Intracranial hemorrhage (ICH) is a type of stroke which occurs most commonly due to the effects of hypertension (high blood pressure) causing rupture of a fragile blood vessel and bleeding directly into the brain. This condition occurs in 11 to 31 of 100,000 Caucasians, and at about 1.4 times that rate in African Americans and Asians. For Washington's 5.8M citizens, that is up to 2,000 patients per year. Thirty day mortality in ICH is estimated at 40 to 60%, with most deaths occurring in-hospital.

This Pilot Human Safety Study will evaluate a combination of recombinant tissue plasminogen activator (rt-PA) and catheter delivered ultrasound in patients with ICH for clot lysis and drainage of the hemorrhage. Catheter delivered, ultrasound enhanced thrombolysis has been shown in more than 1,000 patients to be safe and effective when introduced inside the blood vessels in the peripheral and neuro-vasculature.

This proposal is for a Pilot Human Use Safety Study of a new therapy for ICH. We will combine a novel technology of image-guided surgical catheter placement (GPS guidance within the brain) with delivery of rt-PA and ultrasound enhancement, for clot lysis and drainage. This is an opportunity to change the practice of medicine, with ultrasound and drug delivery catheters that were developed, and are manufactured, in Washington state. The success of this effort will affect a large population of the state's most ill patients. Success in the market will increase the company's production and support staff in Washington.

See also:

Stroke Management

Grant Update

Principal Investigator:
David Newell
Grantee Organization:
Swedish Medical Center
Grant Title:
IHUT (Intracranial and Intraventricular Hemorrhage with Ultrasound Enhanced Thrombolysis)
Grant Cohort and Year:
2007 Beneficial Applications of Technology in Health Care: Improving Health-Care Quality and Cost Effectiveness (01)
Grant Period:
12/01/2007 - 11/30/2009 (Completed)
Grant Amount:
$169,022

Impact in Washington

Location of LSDF Grantee
Locations of Collaborations/Areas of Impact
Seattle
Bothell

Legislative Districts:
1, 11, 34, 36, 37, 43, 46

Health Impacts

Stroke Management