Next Generation Clinical Proteomics to Target Human Health Challenges


To develop a new proteomics technology for the large-scale study of proteins and apply this technology in search of biomarkers for liver disease

Anticipated Impact: 

Earlier, less invasive diagnosis, monitoring, and management of chronic disease


The investigators will develop and apply new technology to find blood proteins that reveal the earliest signs of chronic liver disease. The goal is to establish a safer, non-invasive, easier diagnostic process for liver fibrosis than liver biopsy, allowing an earlier intervention at lower cost and reduced levels of illness and patient discomfort. In Washington State, more than 4,000 people are diagnosed annually with liver disease caused by hepatitis C virus (HCV). About half are cured with a cost of $13 million for diagnosis. This team's technology platform would enable earlier diagnosis of HCV and is projected to increase successful treatment rates by nearly ten percent. Integral to this program is the extension of the technology platform to address problems in other diseases and to make it commercially available for broad clinical use.

See also:


Liver Fibrosis Diagnosis

Grant Update

Principal Investigator:
Richard Smith
Grantee Organization:
Battelle, Pacific Northwest Division
Grant Title:
Next Generation Clinical Proteomics to Target Human Health Challenges
Grant Cohort and Year:
2007 Innovative Programs to Advance Health Research (02)
Grant Period:
08/11/2008 - 08/10/2012 (Completed)
Grant Amount:
Collaborating Organizations:
University of Washington
Concluding efforts for this LSDF funded program project have included the final statistical analysis of the liver transplant and non-liver transplant patient data and the continued preparation of manuscripts for publication reporting the aspects of the technical analytical platform as well as the characterized fibrosis biomarkers.

Impact in Washington

Location of LSDF Grantee
Locations of Collaborations/Areas of Impact

Legislative Districts:
8, 11, 34, 36, 37, 43, 46

Health Impacts

Liver Fibrosis Diagnosis