Center for Intracellular Delivery of Biologics

Focus: 

To better deliver drugs to their site of action within cells

Anticipated Impact: 

Enhanced treatment of cancer, lung injury, and other major disorders with fewer side effects

Abstract: 

With mainstream delivery methods a drug often gets 'lost' and does not reach the proper area within a patient's body to have the designated effect. A multi-disciplinary research center with three cores - drug characterization, smart delivery systems, and preclinical models - will be created where scientists will develop new approaches for delivering biological drugs inside human cells. Highly-targeted delivery and release of these drugs to their sites of action inside the cells optimize drug therapy in defined cell populations and minimize damage to other areas of the body.

Cancer and pulmonary trauma are leading causes of death in Washington and across the nation and result in millions of inpatient hospital days. Using polymer chemistry and nanotechnology, the center investigators will develop new technology platforms by evaluating the safety and effectiveness of drug delivery systems for these medical conditions. This program will identify new intracellular drug vehicles for clinical use that could result in many new commercialization opportunities.

See also:

Lung Injury Therapies
Lymphoma Therapies

Grant Update

Principal Investigator:
Patrick Stayton
Grantee Organization:
University of Washington
Grant Title:
Center for Intracellular Delivery of Biologics
Grant Cohort and Year:
2008 Innovative Programs to Advance Health Research (02)
Grant Period:
08/24/2009 - 08/23/2014 (Completed)
Grant Amount:
$7,163,211
Collaborating Organizations:
Fred Hutchinson Cancer Research Center
With mainstream delivery methods a drug often gets 'lost' and does not reach the proper area within a patient's body to have the designated effect. A multi-disciplinary research center with three cores - drug characterization, smart delivery systems, and preclinical models - will be created where scientists will develop new approaches for delivering biological drugs inside human cells. Highly-targeted delivery and release of these drugs to their sites of action inside the cells optimize drug therapy in defined cell populations and minimize damage to other areas of the body. Cancer and pulmonary trauma are leading causes of death in Washington and across the nation and result in millions of inpatient hospital days. Using polymer chemistry and nanotechnology, the center investigators will develop new technology platforms by evaluating the safety and effectiveness of drug delivery systems for these medical conditions. This program will identify new intracellular drug vehicles for clinical use that could result in many new commercialization opportunities.

Impact in Washington

Location of LSDF Grantee
Locations of Collaborations/Areas of Impact
Seattle

Legislative Districts:
11, 34, 36, 37, 43, 46

Health Impacts

Lung Injury Therapies
Lymphoma Therapies