Cutaneous Healing into Porous Biomaterials Impedes Infection


To test the ability of a percutaneous catheter to resist infection

Anticipated Impact: 

Reduced morbidity and mortality in patients with skin-penetrating devices and commercialization of the novel device by a Washington-based company


Percutaneous (skin-penetrating) devices such as vascular and dialysis catheters, glucose monitors, and artificial prostheses are essential for medical care. The use of these critical devices, however, is associated with high risk of infection leading to significant morbidity and mortality. The proposed work is a new approach that uses material into which the skin can heal, thus providing a barrier to microbial attachment and infection. The proposed work will test whether cutaneous integration into biomaterial inserted into the skin will resist bacterial challenge by Staphylococcus aureus, an organism that commonly infects percutaneous devices. The commercialization plan continues a fruitful collaboration with Healionics, a successful start-up biotech company that has licensed the technology from the University of Washington.

2011 LSDF/WBBA Open House Poster

Catheter-Related Infection Prevention

Grant Update

Principal Investigator:
Philip Fleckman
Grantee Organization:
University of Washington
Grant Title:
Cutaneous Healing into Porous Biomaterials Impedes Infection
Grant Cohort and Year:
2009 Winter Commercialization (03)
Grant Period:
11/03/2009 - 11/02/2010 (Completed)
Grant Amount:
Collaborating Organizations:
A model to test the hypothesis that precisely engineered porous biomaterial will encourage skin incorporation and discourage infection around the material has been developed.

Impact in Washington

Location of LSDF Grantee
Locations of Collaborations/Areas of Impact

Legislative Districts:
11, 34, 36, 37, 43, 46

Health Impacts

Catheter-Related Infection Prevention