Shock Early Detection


<p>To improve the team&rsquo;s prototype device for early detection of medical shock and collect clinical data using the enhanced prototype</p>

Anticipated Impact: 

<p>Improved outcomes in shock patients</p>


Early detection of shock – which is characterized by insufficient oxygen in body tissues – has been shown to be lifesaving, yet no single direct indicator of early shock currently exists. As many as 40% of patients presenting with shock die, despite aggressive medical intervention. Given the high mortality rate of shock and the large expense of not recognizing it in its early stages, there exists a significant need for a new tool to diagnose and monitor shock. Dr. Schenkman’s team has developed novel noninvasive technology to detect and monitor shock via measurement of muscle oxygenation and has collected data on clinical effectiveness through a prior LSDF grant. The goals of the new grant are to improve the probe used to measure muscle oxygenation and complete a proof-of-concept study on trauma patients. The data from this study will be used to attract investment funding to complete development and create a new Washington company to commercialize the device.

Collaborating organizations: Shockmetrics, Stratos

Shock Early Detection

Grant Update

Principal Investigator:
Kenneth Schenkman
Grantee Organization:
University of Washington
Grant Title:
Muscle Oxygenation for Noninvasive Stratification of Shock Severity
Grant Cohort and Year:
2011 First Round Commercialization (03)
Grant Period:
01/01/2012 - 12/31/2012 (Completed)
Grant Amount:
Our project is to develop a new noninvasive device to determine how well oxygen gets into muscle. This device may prove to be very important in helping clinicians determine when patients at risk for shock still need further medical intervention. We have successfully developed an improved optical probe that helps us get high quality optical data from subjects and patients. This improved optical probe has been tested and has allowed higher success rates with data acquisition than our previous probe. We have collected spectra from healthy subjects that form the basis of the analysis algorithm used to determine muscle oxygenation in sick patients. Data from sick patients as a result of traumatic injuries or from infection (sepsis) has been collected. Results from our device show that in both types of shock, noninvasively determined muscle oxygenation can distinguish healthy from sick people. In addition, muscle oxygenation is lower in patients with more severe shock than in those with less severe shock.

Impact in Washington

Location of LSDF Grantee
Locations of Collaborations/Areas of Impact

Legislative Districts:
11, 34, 36, 37, 43, 46

Health Impacts

Shock Early Detection