Improved Diagnosis of Healthcare-Associated Infections


To develop and evaluate a rapid test to detect infections that are commonly contracted in hospitals

Anticipated Impact: 

Improved speed and accuracy of diagnosis of bacterial infections, resulting in better patient outcomes and lower medical costs


Healthcare-associated infections (HAIs) result in billions of dollars in preventable medical costs annually in the US. HAIs can be difficult or slow to diagnose, and thus patients are often treated incorrectly or unnecessarily. Dr. Cangelosi and his team will develop and evaluate a rapid and accurate diagnostic test for HAIs, utilizing high-sensitivity, high-specificity molecular viability testing technology. The commercialization partner is AttoDx, a Seattle start-up company that has an exclusive license to the underlying intellectual property. AttoDx will build an instrument to automate the test in parallel with the LSDF grant.

Collaborating organization: AttoDx

Infectious Disease Diagnosis, Treatment

Grant Update

Principal Investigator:
Gerard Cangelosi
Grantee Organization:
University of Washington
Grant Title:
Improved diagnosis of healthcare-associated infections
Grant Cohort and Year:
2012 First Round Commercialization (03)
Grant Period:
05/16/2013 - 05/15/2015 (Completed)
Grant Amount:
The project aimed to validate and begin commercialization of a novel diagnostic paradigm for ventilator-associated pneumonia (VAP) and other healthcare-associated infections (HAI). Over the course of the extended project we completed most milestones and accomplished key scientific and commercialization goals. Highlights include two peer-reviewed publications; award of a new NIAID STTR Phase 1 grant to the project consortium; issuance (or close to it in some cases) of patents in the U.S., Japan, Australia, China, and the European Union; establishment of new corporate partnerships; and identification of a new diagnostic paradigm resulting in a Record of Innovation (ROI) filed with the University of Washington.

Impact in Washington

Location of LSDF Grantee
Locations of Collaborations/Areas of Impact

Legislative Districts:
11, 34, 36, 37, 43, 46

Health Impacts

Infectious Disease Diagnosis, Treatment