Platelet-Dx: an innovative, point-of-care product for detecting trauma-induced coagulation problems and improving emergency medicine

Focus: 

To develop a prototype device to assess risk of internal bleeding in trauma patients

Anticipated Impact: 

More rapid and appropriate treatment of trauma patients subject to hemorrhaging, and cost savings for unnecessary treatment and blood products

Abstract: 

Trauma is the leading killer of people under the age of 44, and trauma cases in Washington have tripled over the last 15 years. Trauma patients are often at risk of internal bleeding – a major cause of mortality – due to injury to platelets, a component of blood important to blood clotting. Unfortunately, there is no suitable method for detecting platelet injury. Dr. Sniadecki and his colleagues are developing Platelet-Dx, a handheld device that will rapidly assess platelet function and bleeding risk in the field and/or the hospital, both saving lives (by allowing medical personnel to treat patients appropriately) and facilitating efficient management of limited blood products. The LSDF grant will support building of a prototype instrument that can be used for bench top and preclinical studies. The University of Washington Center for Commercialization has assembled a team to help translate this technology into a commercial product.

Platelet Function Monitoring

Grant Update

Principal Investigator:
Nathan Sniadecki
Grantee Organization:
University of Washington
Grant Title:
Platelet-Dx: an innovative, point-of-care product for detecting trauma-induced coagulation problems and improving emergency medicine
Grant Cohort and Year:
2012 First Round Commercialization (03)
Grant Period:
07/01/2013 - 06/30/2014 (Completed)
Grant Amount:
$250,000
Coagulopathy occurs in 1 in for severely injured trauma patients, but there is no suitable point-of-care device that can test for bleeding risk in a trauma patient. For this reason, we have developed and tested a bench-top prototype in which blood samples can be tested for coagulopathy using a microfluidic card. The prototype develop with this LSDF grant uses a portable computer and custom software to control each subsystem. A syringe pump is operated by the software to flow a small sample of blood into the microfluidic card. A commercial heater controller is used to maintain the microfluidic card and blood sample at 37°C. A custom-built, miniature fluorescent microscope acquires video images of coagulation in the microfluidic card for real-time analysis. The prototype is a complete, stand-alone system that has a small footprint. It will be used for in vitro testing and clinical studies for coagulopathy.

Impact in Washington

Location of LSDF Grantee
Locations of Collaborations/Areas of Impact
Seattle

Legislative Districts:
11, 34, 36, 37, 43, 46

Health Impacts

Platelet Function Monitoring