Smart External CSF Drain


To set up pilot production and test a smart external drain system in preparation for commercialization

Anticipated Impact: 

Safer management of cerebrospinal fluid volume and intracranial pressure and reduced clinical staff burden


External ventricular drains are placed to reduce intracranial cerebrospinal fluid (CSF) volume and lower intracranial pressure (ICP) in situations such as brain trauma, brain hemorrhage, stroke, brain tumors, and hydrocephalus. Among other drawbacks, current drain systems require frequent adjustments by nurses to control drainage rate and require patients to remain completely still. An LSDF Commercialization grant to the University of Washington supported development of a prototype smart external drain (SED) that automatically maintains proper CSF drainage in response to changes in CSF production rate and patient position. Aqueduct Neurosciences, Inc. (ANI) was formed to commercialize the SED and related technologies. The grant to ANI supports two iterations of SED prototype construction and testing. LSDF granted a supplement of $70,799 in June 2014 to permit incorporation of unanticipated design improvements into the prototypes to enhance functionality. Successful completion of this grant is expected to put ANI in a strong position for private investment to carry the SED to market launch and sales.

Intracranial Pressure Management

Grant Update

Principal Investigator:
Tom Clement
Grantee Organization:
Aqueduct Neurosciences, Inc.
Grant Title:
Smart External CSF Drain
Grant Cohort and Year:
2013 Proof of Concept (03)
Grant Period:
09/02/2013 - 09/01/2015 (Completed)
Grant Amount:
Our company, Aqueduct, has now successfully completed the work identified under the LSDF grant application. We now have a documented design of our product which can now be built to our written specifications and then tested to produce data for a FDA submission

Impact in Washington

Location of LSDF Grantee
Locations of Collaborations/Areas of Impact

Legislative Districts:

Health Impacts

Intracranial Pressure Management

Feb 5, 2016
Puget Sound Business Journal