Healing Tooth: Engineered Peptides for Transformative Dental Care

Focus: 

To further develop a product that can safely and easily treat, and possibly reverse, early tooth decay

Anticipated Impact: 

Better treatment of early tooth decay, preventing progression to cavities, with resulting cost savings and a better patient experience

Abstract: 

Tooth decay, once started, can be slowed but not prevented. Proposed is a treatment that would restore the tooth surface through remineralization, and would be applied by dentists to teeth that had initiated decay. The potential exists to reverse and prevent tooth decay, a considerable economic and moderate health impact. A skilled entrepreneur is on the team, and commercial aspects have been solidified. The workplan includes refining the formulation of the product into a stable gel; experiments on extracted teeth and in an animal model to demonstrate effectiveness; and work on regulatory approval.

Collaborating organizations: Auxin Group; CPCScientific; AmbioPharm, Inc.; University of Connecticut Health Center School of Dental Medicine

Tooth Decay Prevention, Detection, Treatment

Grant Update

Principal Investigator:
Mehmet Sarikaya
Grantee Organization:
University of Washington
Grant Title:
Healing Tooth: Engineered Peptides for Transformative Dental Care
Grant Cohort and Year:
2013 Proof of Concept (03)
Grant Period:
12/01/2013 - 11/30/2015 (Completed)
Grant Amount:
$249,979
A gel based formulation, similar to that of a toothpaste, incorporating a mineral directing peptide along with calcium and phosphate has been successfully developed. After showing successful remineralization, ex vivo, on extracted teeth, an in vivo remineralization study via a rat model has been completed. New mineral layers were established after 2 weeks of treatment on rats with carious lesions. The outcomes from this study will serve as the basis for further commercial development into dental product(s) for treating demineralization related dental ailments such as reversing early stage caries, hypersensitivity, and biogenic dental composites.

Impact in Washington

Location of LSDF Grantee
Locations of Collaborations/Areas of Impact
Seattle

Legislative Districts:
11, 34, 36, 37, 43, 46

Health Impacts

Tooth Decay Prevention, Detection, Treatment