A Point-of-Care Device to Rapidly Diagnose Trauma-Induced Coagulopathy

Focus: 

To develop a prototype device to assess risk of internal bleeding in trauma patients

Anticipated Impact: 

More rapid and appropriate treatment of trauma patients subject to hemorrhaging, and cost savings for unnecessary treatment and blood products

Abstract: 

Trauma is the leading killer of people under the age of 45, and trauma cases in Washington have tripled over the last 15 years. Trauma patients are often at risk of internal bleeding – a major cause of mortality – due to injury to platelets, a component of blood important to blood clotting. Unfortunately, there is no suitable method for detecting platelet injury. Dr. Nathan Sniadecki and his colleagues are developing Platelet-Dx, a handheld device that will rapidly assess platelet function and bleeding risk in the field and/or the hospital, both saving lives (by allowing medical personnel to treat patients appropriately) and facilitating efficient management of limited blood products. The LSDF grant will support enhancement of a prototype instrument (being constructed with a previous LSDF grant) that can be used for bench top and preclinical studies. An observational clinical trial comparing the prototype to the commonly used but much slower devices, TEG and ROTEM, will be conducted at Harborview Medical Center. The University of Washington (UW) Center for Commercialization has assembled a team to help translate this technology into a commercial product, and a startup company, Stasys Medical, is collaborating.

LSDF Opportunity grant funding will be matched by $290,000 in contributions from the Coulter Translational Research Partnership Program at UW, the Institute of Translational Health Sciences, the UW Center for Commercialization, and the Washington Research Foundation.

Collaborating organization: Stasys Medical

Platelet Function Monitoring

Grant Update

Principal Investigator:
Patrick Shelby
Grantee Organization:
University of Washington
Grant Title:
A Point-of-Care Device to Rapidly Diagnose Trauma-Induced Coagulopathy
Grant Cohort and Year:
2013 Opportunity (05)
Grant Period:
01/01/2014 - 12/31/2015 (Completed)
Grant Amount:
$100,000
The enrollment for the observational trial is continuing with some delays. Data will be analyzed and reported in publication upon completion of the targeted enrollment.

Impact in Washington

Location of LSDF Grantee
Locations of Collaborations/Areas of Impact
Seattle

Legislative Districts:
11, 34, 36, 37, 43, 46

Health Impacts

Platelet Function Monitoring

Feb 18, 2015
The Daily of the University of Washington