Injectable, Thermoreversible Polymers for the Localization of Non-palpable Breast Cancers


To assess safety and performance of a novel technology for localizing non-palpable breast tumors during surgery

Anticipated Impact: 

More complete excision of breast cancer tissue during surgery and reduced need for additional surgery


Dr. Tarasevich and colleagues are developing a temperature-sensitive polymer to improve the surgical excision of non-palpable breast lesions, including ductal carcinoma in situ (DCIS) and invasive cancers, and reduce re-excision rates. The product would be injected into the lesion area during pre-operative mammography, instead of the wire that is currently used, to create a palpable, three-dimensional target for the surgeon. LSDF funding will support preclinical safety and performance testing. A Washington-based start-up company, Malignext Targeting Technologies, is the commercialization partner.

Collaborating organizations: Malignext Targeting Technologies, Washington State University

A supplement was awarded to evaluate whether inflammation is caused by mechanical damage from placing the product in the location to be marked.

Breast Cancer Prognosis, Therapies

Grant Update

Principal Investigator:
Barbara Tarasevich
Grantee Organization:
Pacific Northwest National Laboratory
Grant Title:
Injectable, Thermosensitive Polymers for the Localization of Non-palpable Breast Cancers
Grant Cohort and Year:
2015 Proof of Concept (03)
Grant Period:
05/15/2015 - 05/14/2018 (Completed)
Grant Amount:
Novel injectable, thermogelling polymers are being developed as three dimensional markers for the localization of non-palpable breast cancers. The polymer gels are stronger than breast tissue and can be palpated, guiding the surgeon to the cancerous lesion. The polymers have been developed to be visible by ultrasound and x-ray allowing accurate localization.

Impact in Washington

Location of LSDF Grantee
Locations of Collaborations/Areas of Impact

Legislative Districts:
8, 9, 17, 49

Health Impacts

Breast Cancer Prognosis, Therapies