Zip Clip. Endoscopic treatment for bleeding and perforation.


To develop and test an advanced prototype of an endoscopic clip to stop gastrointestinal (GI) bleeding

Anticipated Impact: 

Faster and more effective treatment of GI bleeding


Bleeding within the gastrointestinal (GI) tract leads to over 400,000 hospitalizations per year in the US. Endoscopy is commonly performed to identify the sources of GI bleeding and to control such bleeding using clips. However, difficulties in positioning and grasping tissue limit the effectiveness of current clips in many situations. Dr. Merrifield and his business partner at EndoGear, both practicing gastroenterologists and experienced inventors, have developed the ZipClip to address the shortcomings of current clips. The ZipClip can be used with lesions of varying sizes and locations, and multiple clips can be deployed in rapid succession. As such, EndoGear anticipates that the ZipClip will enable faster and more durable closure of GI defects using fewer clips, translating into less medical waste and lower costs. The LSDF grant is supporting iterative development and bench testing of refined ZipClip prototypes; construction of a high-fidelity prototype using (to the extent possible) final manufacturing processes and materials; and preclinical testing in the laboratory of a leading gastroenterologist. EndoGear expects that the advanced prototype and preclinical data will attract additional investment and/or strategic industry partnerships to move the ZipClip through regulatory approval, manufacturing, and market entry.

Collaborating organizations: Product Creation Studio, Brigham and Women's Hospital/Harvard Medical School

Gastrointestinal Disease Diagnosis, Treatment

Grant Update

Principal Investigator:
Benjamin Merrifield
Grantee Organization:
Grant Title:
Zip Clip Endoscopic Hemostasis Device.
Grant Cohort and Year:
2015 Proof of Concept (03)
Grant Period:
07/01/2015 - 06/30/2017 (Completed)
Grant Amount:
Over the course of the past six months we have continued to refine our clip to reach our our goal of creating a novel endoscopically delivered hemostatic clip. Based on ongoing bench testing, we improved the design to achieve improved function. Our clip can be deployed using a standard endoscope and manipulated using common endoscopic maneuvers. We have successfully conducted through the scope testing of our clip and have refined our design to make the clip more intuitive, accurate, and manufacturable. We have also filed a patent for our novel clip technology and recently been accepted into the USPTO Patent Highway Program. We have employed a company which was able to successfully manufacture our clip based on our design specifications.

Impact in Washington

Location of LSDF Grantee
Locations of Collaborations/Areas of Impact

Legislative Districts:
11, 34, 36, 37, 43, 46

Health Impacts

Gastrointestinal Disease Diagnosis, Treatment