Integrated Chip-Scale Blood Testing for Transfusion Medicine

Focus: 

To validate a rapid blood-typing diagnostic device

Anticipated Impact: 

Rapid and inexpensive blood typing, with the potential for other blood-based analyses

Abstract: 

Blood typing occurs multiple times during the blood transfusion process but still uses the century-old technique of agglutination, which is slow, somewhat expensive, and requires human intervention. The proposed platform – a novel silicon chip "printed" with reagent wells and reagents and read by a laser –will initially be developed for blood typing. Because the chip can be multiplexed, several simultaneous analyses (such as for infectious agents) could be performed. The workplan includes producing chips at a commercial scale and validating the chips' ability to type blood in 200 samples. 

A supplement was awarded to multiplex indirect and direct screening for the Kell antigen/antibodies to the chip.             

Collaborating organizations: Institute of Translational Health Sciences, University of Washington

Blood Typing

Grant Update

Principal Investigator:
Jill Johnsen
Grantee Organization:
Bloodworks Northwest
Grant Title:
Integrated Chip-Scale Blood Testing for Transfusion Medicine
Grant Cohort and Year:
2015 Proof of Concept (03)
Grant Period:
08/01/2015 - 07/31/2018 (Active)
Grant Amount:
$350,000
In this third reporting period, we continue to make progress in proof-of-concept and validation of a silicon photonics platform for blood typing. Specifically, we have functionalized silicon chips at scale for blood type testing and begun larger scale testing in 200 blood donors.

Impact in Washington

Location of LSDF Grantee
Locations of Collaborations/Areas of Impact
Seattle

Legislative Districts:
11, 34, 36, 37, 43, 46

Health Impacts

Blood Typing